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    Science FridayHow A Fringe Idea Led To Lifesaving Cancer Treatments
    30 minEpisode 1185

    How A Fringe Idea Led To Lifesaving Cancer Treatments

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    In cancer research, the “seed and soil” hypothesis posits that the tumor is like a seed of misbehaving cells taking root in the body. Whether it grows—and where it grows—depends on the conditions, or soil. Since this hypothesis was proposed more than 100 years ago, most research and treatments have focused on the seed, or tumor.

    For nearly 50 years, Rakesh Jain has been studying the soil. But in a seed-focused field, his work was seen as wasteful and radical. Now, that very same research has led to seven FDA-approved treatments for diseases including lung and liver cancer, and earned him a National Medal of Science in 2016. Host Flora Lichtman talks with Jain about how his fringe idea led to lifesaving cancer treatments.

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    © Science Friday and WNYC StudiosLength 30 min10 December 2025Episode 1185ScienceFactsEducationalUSAEpisodic

    Agricultural Bees, China’s Energy Future, Frankenstein In Class. Feb 2, 2018, Part 1

    Agricultural Bees, China’s Energy Future, Frankenstein In Class. Feb 2, 2018, Part 1

    This is an episodic podcast, so you can listen to it in any order, but episode one is a great place to start.

    Listen to episode one here
    11+ScienceFactsEducationalUSAEpisodic10 December 2025© Science Friday and WNYC Studios

    In cancer research, the “seed and soil” hypothesis posits that the tumor is like a seed of misbehaving cells taking root in the body. Whether it grows—and where it grows—depends on the conditions, or soil. Since this hypothesis was proposed more than 100 years ago, most research and treatments have focused on the seed, or tumor.

    For nearly 50 years, Rakesh Jain has been studying the soil. But in a seed-focused field, his work was seen as wasteful and radical. Now, that very same research has led to seven FDA-approved treatments for diseases including lung and liver cancer, and earned him a National Medal of Science in 2016. Host Flora Lichtman talks with Jain about how his fringe idea led to lifesaving cancer treatments.

    Guest: Dr. Rakesh K. Jain studies the biology of tumors at Harvard Medical School and Massachusetts General Hospital as a professor of radiation oncology.

    Transcripts for each episode are available within 1-3 days at sciencefriday.com.

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    © Science Friday and WNYC Studios |Original Episode URL. The content, artwork and advertising within this podcast is not owned or affiliated with Sound Carrot and remain the property of their respective owners.


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