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    Science FridayWhat’s That Smell? An AI Nose Knows
    12 minEpisode 654

    What’s That Smell? An AI Nose Knows

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    If you want to predict the color of something, you can talk about wavelengths of light. Light with a wavelength of around 460 nanometers is going to look blue. If you want to predict what something sounds like, frequencies can be a guide—a frequency of around 261 Hertz should sound like the musical note middle C.

    Predicting smells is more difficult. While we know that many sulfur-containing molecules tend to fall somewhere in the ‘rotten egg’ or ‘skunky’ category, predicting other aromas based solely on a chemical structure is hard. Molecules with a similar chemical structure may smell quite different—while two molecules with very different chemical structures can smell the same.

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    © Science Friday and WNYC StudiosLength 12 min29 November 2023Episode 654ScienceFactsEducationalUSAEpisodic

    Agricultural Bees, China’s Energy Future, Frankenstein In Class. Feb 2, 2018, Part 1

    Agricultural Bees, China’s Energy Future, Frankenstein In Class. Feb 2, 2018, Part 1

    This is an episodic podcast, so you can listen to it in any order, but episode one is a great place to start.

    Listen to episode one here
    11+ScienceFactsEducationalUSAEpisodic29 November 2023© Science Friday and WNYC Studios

    If you want to predict the color of something, you can talk about wavelengths of light. Light with a wavelength of around 460 nanometers is going to look blue. If you want to predict what something sounds like, frequencies can be a guide—a frequency of around 261 Hertz should sound like the musical note middle C.

    Predicting smells is more difficult. While we know that many sulfur-containing molecules tend to fall somewhere in the ‘rotten egg’ or ‘skunky’ category, predicting other aromas based solely on a chemical structure is hard. Molecules with a similar chemical structure may smell quite different—while two molecules with very different chemical structures can smell the same.

    This week in the journal Science, researchers describe developing an AI model that, given the structure of a chemical compound, can roughly predict where it’s likely to fall on a map of odors. For example, is it grassy? Or more meaty? Perhaps floral?

    Dr. Joel Mainland is one of the authors of that report. He’s a member of the Monell Chemical Senses Center and an adjunct associate professor in the department of neuroscience at the University of Pennsylvania in Philadelphia. Mainland joins Ira to talk about the mystery of odor, and his hope that odor maps like the one developed by the AI model could bring scientists closer to identifying the odor equivalent of the three primary colors—base notes that could be mixed and blended to create all other smells.

    To stay updated on all things science, sign up for Science Friday’s newsletters. Transcripts for each segment will be available after the show airs on sciencefriday.com.

    Subscribe to this podcast. Follow our show on Instagram, TikTok, Facebook, and Bluesky @scifri and sign up for our newsletters. Got a science question that’s keeping you up at night? Call us: 877-472-4374

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    © Science Friday and WNYC Studios |Original Episode URL. The content, artwork and advertising within this podcast is not owned or affiliated with Sound Carrot and remain the property of their respective owners.


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