CRISPR-Based Sickle Cell Treatment | Pain Tolerance From Neanderthals

If given final approval by the FDA, this sickle-cell treatment would be the first to use gene-editing CRISPR technology on humans. Also, gene variants inherited from Neanderthals can impact pain tolerance in modern humans.

FDA Panel Clears Way For CRISPR-Based Sickle Cell TreatmentAn FDA committee cleared the way for a revolutionary cure for sickle cell disease this week. If given final approval, the treatment would be the first to use CRISPR gene editing in humans. Sickle cell disease is caused by a genetic mutation that causes blood cells to develop into crescent or “sickle” shapes. The extremely painful and often deadly disease disproportionately affects Black and African American people.

Ira talks with Vox staff writer Umair Irfan about the new sickle cell treatment and other top science news of the week, including the link between the auto worker strike and a clean energy transition; new evidence about the moon’s origin; and why starfish don’t have arms.

Your Pain Tolerance May Have Been Passed Down from NeanderthalsThere’s a little bit of Neanderthal in most of us. Neanderthals and Homo sapiens had a long history of intermingling, before the former went extinct about 40,000 years ago. That mixing means most modern humans have some amount of Neanderthal DNA—and it accounts for up to 3% of the genome in some people.

While these genetic remnants don’t have much impact on our day-to-day lives, they may be responsible for one surprising effect: pain tolerance. Recent research shows that people with Neanderthal variants in the gene SCN9A have a lower pain tolerance than people without the gene.

This isn’t the only Neanderthal remnant that’s been passed down. A study from earlier this year pinpointed a certain genome region that impacts nose shape. Taller, wider noses were passed down from our Neanderthal ancestors who lived in colder climates. A larger nose warmed air before it hit the sensitive lungs.

Ira speaks with Dr. Kaustubh Adhikari, assistant professor of statistics at the Open University in the United Kingdom, who worked on both of these studies.

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